Beilstein J. Org. Chem.2022,18, 446–458, doi:10.3762/bjoc.18.47
hours, which provides an environmentally friendly access to 3,4,5-trisubstituted isoxazoles, an important class of structures found in numerous bioactive natural products and pharmaceuticals. Additionally, we optimized the reaction conditions to produce trifluoromethyl-substitutedisoxazoles, a
chlorides to form furoxans also known as 1,2,5-oxadiazole 2-oxides, a class of structures with important biological activities due to their unique electronic nature and coordination ability.
Keywords: environmentally friendly; furoxans; 1,2,5-oxadiazole 2-oxides; trifluoromethyl-substitutedisoxazoles
. Meanwhile, some of the starting material 2l remained unreacted and we suspected the lower solubility of compound 2l in water was responsible for the low yield of the reaction. Since trifluoromethyl-substitutedisoxazoles are an important and prevalent scaffold in biomedical research and drug discovery